A recent study indicates that individuals who discontinue popular GLP-1 drugs like semaglutide or tirzepatide can put back on lost weight far faster than those who halt conventional lifestyle programs.
Research printed in a prominent medical journal shows that while overweight people can lose substantial amounts of their body weight while undergoing treatment, the weight returns at an average rate of nearly a kilo each month upon discontinuation.
"People using such drugs need to be cognizant of the risk of fast weight regain when the therapy is stopped," cautioned lead investigator Dr. Susan Jebb.
That rate of regain implies a return to pre-treatment weight in about a year and a half.
Weighing Therapies
The analysis, which reviewed dozens of trials involving over 9,000 of patients, contrasted the results of these new drugs with older methods.
Scientists point out that people who shed pounds through diet and exercise typically have a less rapid weight regain—around 100 grams monthly—once they finish.
Explaining the Fast Regain
Experts believe the mode of action of the jabs explains the heightened rebound.
GLP-1 drugs mimic a natural hormone called glucagon-like peptide-1, which helps regulate feelings of fullness.
"Sustained high doses of GLP-1 levels far above than normal may cause the system to produce less of its endogenous GLP-1, and may also reduce responsiveness to its effects," said Dr. Adam Collins, a dietetics researcher.
"Stopping of this hormone supplement results in hunger is uncontrolled, making binge eating much more probable."
An Ongoing Disease?
Health authorities recommend the injections for people with obesity-related health risks, alongside prescribed lifestyle changes.
A number of clinicians argue that, due to the high risk of weight regain, the treatment should be considered ongoing.
This opinion is echoed by drug manufacturers, who state that the results "underscore the chronic nature of excess weight," akin to managing diseases like hypertension.
User Experiences
Individuals who have come off the medication describe a sudden resurgence of hunger.
"I experienced a trigger that goes on and you're instantly starving," recalled an individual.
This challenge is compounded if users have not developed permanent dietary or behavioural changes during treatment.
Widespread Use
Survey data indicate that millions of adults in the UK have used these injections in the last 12 months, with desire being substantial.
- Use is greater among women compared to males.
- The 40s and 50s age group shows the highest level of interest.
- Many obtain the drugs through private prescriptions rather than public health services.
Finally, researchers stress that while these medications are potent agents for shedding pounds, they are not a magic cure and maintained weight loss likely depends on ongoing lifestyle support.
